Renal denervation in the most serious form of resistant arterial hypertension

The aim of our observation was to establish whether or not renal sympathetic denervation (RSD) may help control blood pressure (BP) levels in patients with severe hypertension refractory to pharmacological therapy. Out of a group of 12 patients, candidates for RSD, with uncontrolled hypertension and...

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Bibliographic Details
Published inPhysiological research Vol. 65; no. 6; pp. 909 - 916
Main Authors Šochman, J, Bürgelová, M, Peregrin, J H
Format Journal Article
LanguageEnglish
Published Czech Republic Institute of Physiology 01.01.2016
Subjects
Aged
Antihypertensive Agents - adverse effects
Antihypertensive Agents - therapeutic use
Biomarkers
Blood Pressure
Catheters
Drug dosages
Drug Resistance
Female
Follow-Up Studies
Humans
Hypertension
Hypertension, Renal - drug therapy
Hypertension, Renal - surgery
Kidney - innervation
Kidney - surgery
Kidney Function Tests
Length of Stay
Male
Metabolism
Middle Aged
Patients
Rodents
Studies
Sympathectomy
Treatment Outcome
Veins & arteries
United States > US
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Summary:The aim of our observation was to establish whether or not renal sympathetic denervation (RSD) may help control blood pressure (BP) levels in patients with severe hypertension refractory to pharmacological therapy. Out of a group of 12 patients, candidates for RSD, with uncontrolled hypertension and a systolic BP over 190 mm Hg on repeated measurements despite optimal medication, four patients were excluded for multiple renal arteries and one for hyperaldosteronism. Seven patients had RSD using a Symplicity device (5M, 2 F) with a mean age of 64.9 years. While all were followed up for a minimum of 6 months, follow-up duration in the majority of them was substantially longer (12-20 months). At six months post-RSD, six of the seven patients showed a decrease in systolic BP by at least 15 mm Hg while receiving the same or fewer doses of antihypertensive agents. A similar response was seen in diastolic BP. The BP decrease was maintained throughout whole follow-up. In a small group of patients with severe hypertension, we demonstrated that renal sympathetic denervation is capable of reducing blood pressure even in patients with severe hypertension.
ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.933238