A new fluorescent assay for enalapril maleate

A new spectrofluorimetric method for the enalapril maleate monitoring was studied. Enalapril maleate was found to be highly photolabile. This drug was evaluated according to photodegradation assay at pH 2.5 and 6. Enalapril maleate was exposed to UVA-UVB radiations. Under these specific conditions w...

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Bibliographic Details
Published inJournal of fluorescence Vol. 15; no. 5; pp. 723 - 728
Main Authors de los A Oliva, María, Sombra, Lorena L, Olsina, Roberto A, Masi, Adriana N
Format Journal Article
LanguageEnglish
Published Netherlands 01.09.2005
Subjects
Antihypertensive Agents - chemistry
Antihypertensive Agents - radiation effects
Diketopiperazines
Enalapril - chemistry
Enalapril - radiation effects
Kinetics
Photolysis
Piperazines - analysis
Prodrugs - chemistry
Prodrugs - radiation effects
Spectrometry, Fluorescence - methods
Ultraviolet Rays
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Summary:A new spectrofluorimetric method for the enalapril maleate monitoring was studied. Enalapril maleate was found to be highly photolabile. This drug was evaluated according to photodegradation assay at pH 2.5 and 6. Enalapril maleate was exposed to UVA-UVB radiations. Under these specific conditions was found as degradation product, the diketopiperazine. The modification of the fluorescent properties of enalapril maleate in solution after exposure UV-radiation and the degradation mechanisms were studied. The photodegradation was followed by the developed spectrofluorimetric assay.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1053-0509
1573-4994
DOI:10.1007/s10895-005-2979-3