The circuit of Papez in mesial temporal sclerosis: MRI

We looked at abnormalities in the circuit of Papez in patients with the mesial temporal sclerosis (MTS). We reviewed the MRI studies of 15 patients with probable MTS, seeking changes in the fornix, mamillary body, mamillothalamic tract, thalamus and cingulate and parahippocampal gyri. We correlated...

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Published inNeuroradiology Vol. 43; no. 3; pp. 205 - 210
Main Authors OIKAWA, H, SASAKI, M, TAMAKAWA, Y, KAMEI, A
Format Journal Article
LanguageEnglish
Published Berlin Springer 01.03.2001
Subjects
Adolescent
Adult
Atrophy
Biological and medical sciences
Child
Child, Preschool
Epilepsy, Temporal Lobe - etiology
Epilepsy, Temporal Lobe - pathology
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Infant
Limbic System - pathology
Magnetic Resonance Imaging
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Retrospective Studies
Sclerosis
Temporal Lobe - pathology
Human
Nervous system diseases
Central nervous system disease
Complex partial epilepsy
Medical imagery
Temporal lobe epilepsy
Exploration
Nuclear magnetic resonance imaging
Sclerosis
Cerebral disorder
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Summary:We looked at abnormalities in the circuit of Papez in patients with the mesial temporal sclerosis (MTS). We reviewed the MRI studies of 15 patients with probable MTS, seeking changes in the fornix, mamillary body, mamillothalamic tract, thalamus and cingulate and parahippocampal gyri. We correlated any abnormalities with each other and with clinical severity. Atrophy and/or signal change in one or more structures in the circuit of Papez were found in five patients. They involved the parahippocampal gyri in all five, the fornices in four, mamillary bodies in three, the thalamus in two and the cingulate gyrus in one. Changes in the fornix, mamillary body, thalamus or cingulate gyrus were always accompanied by hippocampal and parahippocampal atrophy. The patients with abnormalities of the circuit of Papez did not have more severe epilepsy than those without. Changes in the parahippocampal gyrus, including the entorhinal cortex and subiculum, in which forniceal fibres originate, may be crucial in causing abnormalities more distally in the circuit.
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ISSN:0028-3940
1432-1920
DOI:10.1007/s002340000463