Antiviral and antibacterial activity of hand sanitizer and surface disinfectant formulations

• Published in: International journal of pharmaceutics Vol. 609; p. 121139
• Main Authors: Filipe, Hugo A.L., Fiuza, Sónia M., Henriques, César A., Antunes, Filipe E.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 20.11.2021
• Subjects: Antibacterial activity; Antiviral activity; Disinfectants; Formulations; Hand sanitizer; Formulations; Antibacterial activity; Disinfectants; Hand sanitizer; Antiviral activity
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2021.121139

[Display omitted] Emergent diseases caused by viral and bacterial infections have proven to be a current and future challenge. The occurrence of these diseases is usually accompanied by the lack of vaccines and dedicated therapies leaving prevention as the best strategy to adopt. In that context, and apart from confinement and physical distancing measures, an increase in hygiene actions, namely hand and surface cleaning and disinfection can reduce the infection spread originated from our day-to-day routines. However, during crisis situations the high disinfectants demand can very likely lead to having them running out of stock. This impels many individuals and companies to produce their own disinfectants. Here, we explore the main components of a disinfection formulation, both for hand-rub and surface cleaning. Alcohol and non-alcohol based formulations are described, including the possibility to fine tune the properties of the final product in order to increase public acceptance while maintaining product efficacy. The action mechanisms of the main active principles are also described conjugating information from experimental and theoretical data. Overall, the main aspects to develop a disinfectant formulation are addressed, as well as their function, helping formulation developers to better understand the impact of their choices.