Reduction of the cAMP response to norepinephrine in rat cerebral cortex following repeated restraint stress

The present studies examined the effect of restraint stress on the sensitivity of the catecholamine-cAMP generating system in the rat cerebral cortex. Restraint was found to cause a persistent reduction in the magnitude of the cAMP response to catecholamines. This effect occurred after repeated but...

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Bibliographic Details
Published inPsychopharmacology Vol. 82; no. 4; p. 403
Main Authors Stone, E A, Platt, J E, Trullas, R, Slucky, A V
Format Journal Article
LanguageEnglish
Published Germany 01.01.1984
Subjects
Animals
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
Cyclic AMP - metabolism
Desipramine - pharmacology
Humans
Isoproterenol - pharmacology
Male
Norepinephrine - pharmacology
Rats
Rats, Inbred Strains
Restraint, Physical
Stress, Psychological - metabolism
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Summary:The present studies examined the effect of restraint stress on the sensitivity of the catecholamine-cAMP generating system in the rat cerebral cortex. Restraint was found to cause a persistent reduction in the magnitude of the cAMP response to catecholamines. This effect occurred after repeated but not acute stress and was more marked with twice-daily as compared to once-daily treatment. The reduction in response was more marked with norepinephrine than with isoproterenol, indicating a selective action of stress on the non-beta component of the noradrenergic response. The findings suggest that subsensitivity of the cAMP response to norepinephrine is a general response to chronic stressful stimuli and may be related to the action of certain antidepressant agents.
ISSN:0033-3158
DOI:10.1007/BF00427695