Family study of genetic and environmental factors determining the protein binding of propranolol

The unbound fraction of propranolol was found to vary from 1.9 to 13.2% in 434 plasma samples from members of 132 families. As expected, there was a linear correlation between the ratio of bound/unbound propranolol and the orosomucoid concentration (r = 0.67, P less than 0.001). Albumin concentratio...

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Bibliographic Details
Published inEuropean journal of clinical pharmacology Vol. 25; no. 4; p. 437
Main Authors Alván, G, Bergström, K, Borgå, O, Iselius, L, Pedersen, N
Format Journal Article
LanguageEnglish
Published Germany 01.01.1983
Subjects
Adult
Child
Female
Humans
Male
Orosomucoid - analysis
Phenotype
Propranolol - metabolism
Protein Binding
Serum Albumin - analysis
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Summary:The unbound fraction of propranolol was found to vary from 1.9 to 13.2% in 434 plasma samples from members of 132 families. As expected, there was a linear correlation between the ratio of bound/unbound propranolol and the orosomucoid concentration (r = 0.67, P less than 0.001). Albumin concentration did not influence propranolol binding. The unbound fraction was negatively correlated with obesity and alcohol intake, but was not significantly influenced by age and sex. By applying path analysis, 21% of the variability in propranolol binding could be ascribed to genetic factors and 5% to common environmental factors.
ISSN:0031-6970
DOI:10.1007/BF00542107