The nervous system and adipose tissues: a tale of dialogues

White, beige, and brown adipose tissues play a crucial role in maintaining energy homeostasis. Due to the heterogeneous and diffuse nature of fat pads, this balance requires a fine and coordinated control of many actors and therefore permanent dialogues between these tissues and the central nervous...

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Bibliographic Details
Published inAmerican journal of physiology: endocrinology and metabolism Vol. 325; no. 5; pp. E480 - E490
Main Authors Lorsignol, Anne, Rabiller, Lise, Labit, Elodie, Casteilla, Louis, Pénicaud, Luc
Format Journal Article
LanguageEnglish
Published Bethesda American Physiological Society 01.11.2023
Subjects
Adipose tissue
Central nervous system
Energy balance
Homeostasis
Innervation
Life Sciences
energy balance
sensory innervation
sympathetic innervation
adipose tissues
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Summary:White, beige, and brown adipose tissues play a crucial role in maintaining energy homeostasis. Due to the heterogeneous and diffuse nature of fat pads, this balance requires a fine and coordinated control of many actors and therefore permanent dialogues between these tissues and the central nervous system. For about two decades, many studies have been devoted to describe the neuro-anatomical and functional complexity involved to ensure this dialogue. Thus, if it is now clearly demonstrated that there is an efferent sympathetic innervation of different fat depots controlling plasticity as well as metabolic functions of the fat pad, the crucial role of sensory innervation capable of detecting local signals informing the central nervous system of the metabolic state of the relevant pads is much more recent. The purpose of this review is to provide the current state of knowledge on this subject.
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ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.00115.2023