Treatment experiences of testicular cancer in Hispanic patients with Down’s syndrome at the National Cancer Institute of Mexico

• Published in: Clinical & translational oncology Vol. 10; no. 11; pp. 768 - 771
• Main Authors: Aguilar-Ponce, José Luis, Vidal-Millán, Silvia, Molina-Calzada, Carlos, Chilaca-Rosas, Fátima, Martínez-Cedillo, Jorge, Cruz-López, Juan Carlos
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 01.11.2008
• Subjects: Abnormalities, Multiple; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Bleomycin - administration & dosage; Brain Neoplasms - secondary; Case Reports; Cisplatin - administration & dosage; Combined Modality Therapy; Cryptorchidism - complications; Down Syndrome - complications; Etoposide - administration & dosage; Fatal Outcome; Humans; Lung Neoplasms - secondary; Lymphatic Metastasis; Male; Medicine; Medicine & Public Health; Mexico; Neoplasms, Germ Cell and Embryonal - complications; Neoplasms, Germ Cell and Embryonal - pathology; Neoplasms, Germ Cell and Embryonal - secondary; Neoplasms, Germ Cell and Embryonal - surgery; Oncology; Orchiectomy; Remission Induction; Retroperitoneal Neoplasms - radiotherapy; Retroperitoneal Neoplasms - secondary; Seminoma - complications; Seminoma - pathology; Seminoma - radiotherapy; Seminoma - surgery; Testicular Neoplasms - complications; Testicular Neoplasms - pathology; Testicular Neoplasms - surgery; Treatment Outcome; Young Adult; Mexico; Seminoma; Therapy; Latin American; Down’s syndrome; Case reports; Mexico; Diagnosis; Testicular cancer; Hispanic; Aetiology
• ISSN: 1699-048X; 1699-3055
• DOI: 10.1007/s12094-008-0286-6

We present 4 case studies of patients with Down’s syndrome and testicular germ-cell cancer, treated with conventional methods at the National Cancer Institute of Mexico, with similar outcomes as patients without this syndrome. There are several reports of testicular cancer arising in patients with Down’s syndrome worldwide, mainly from Caucasian populations. We discuss some theories about the association and the possible increase of incidence.