An Efficient Method for the Large-Scale Synthesis of Atorvastatin Calcium

Atorvastatin calcium salt (1) was obtained through the preparation of lactone compound (8) from 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-ethyl)- 2-phenyl-1,3,2-dioxaborinan-4-yl)acetic acid tert-butyl ester (9) by hydrolysis in basic condition. Eff...

Full description

Saved in:
Bibliographic Details
Published inBiomolecules & therapeutics Vol. 16; no. 1; pp. 28 - 33
Main Authors Lee, Hong-Woo, Kim, Young-Min, Yoo, Choong-Leol, Kang, Sung-Kwon, Ahn, Soon-Kil
Format Journal Article
LanguageEnglish
Published 한국응용약물학회 01.03.2008
Subjects
약학
Online AccessGet full text

Cover

More Information
Summary:Atorvastatin calcium salt (1) was obtained through the preparation of lactone compound (8) from 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-ethyl)- 2-phenyl-1,3,2-dioxaborinan-4-yl)acetic acid tert-butyl ester (9) by hydrolysis in basic condition. Efficient hydrolysis of boronate compound 9 aimed at the viable synthesis for commercial production and purification of Atorvastatin calcium is reported. Detail studies of evaluation procedure are also reported. KCI Citation Count: 10
Bibliography:G704-000363.2008.16.1.007
ISSN:1976-9148
2005-4483
DOI:10.4062/biomolther.2008.16.1.028