Oxygen-dependent mechanisms underlying the antiischemic effect of verapamil and amlodipine

Verapamil and amlodipine produced a potent antiischemic effect and reduced the area of myocardial infarction in rats. The observed changes were accompanied by inhibition of lipid peroxidation. In contrast to verapamil, amlodipine in a dose of 50 ng/ml in vitro decreased hemoglobin affinity for oxyge...

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Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 137; no. 1; pp. 40 - 42
Main Author Gatsura, S V
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.01.2004
Subjects
Amlodipine - pharmacology
Animals
Hemoglobins - metabolism
Lipid Peroxidation - drug effects
Malondialdehyde - blood
Myocardial Infarction - blood
Myocardial Ischemia - blood
Oxygen - blood
Rats
Superoxide Dismutase - blood
Verapamil - pharmacology
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Summary:Verapamil and amlodipine produced a potent antiischemic effect and reduced the area of myocardial infarction in rats. The observed changes were accompanied by inhibition of lipid peroxidation. In contrast to verapamil, amlodipine in a dose of 50 ng/ml in vitro decreased hemoglobin affinity for oxygen. Moreover, amlodipine in a concentration of 2 ng/ml decreased the content of malonic dialdehyde and activity of superoxide dismutase in the blood.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
1573-8221
DOI:10.1023/B:BEBM.0000024382.81356.04