Response to Comments on “Widespread RNA and DNA Sequence Differences in the Human Transcriptome”

Kleinman and Majewski, Pickrell et al ., and Lin et al . suggest that mapping and sequencing errors and genetic variants led to false discovery of RNA-DNA sequence differences in our paper. We repeated our analysis using two different sequence alignment methods and carried out additional experiments...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 335; no. 6074; p. 1302
Main Authors Li, Mingyao, Wang, Isabel X, Cheung, Vivian G
Format Journal Article
LanguageEnglish
Published Washington The American Association for the Advancement of Science 16.03.2012
Subjects
Deoxyribonucleic acid
DNA
Genetics
Genomics
Indexing in process
Ribonucleic acid
RNA
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Summary:Kleinman and Majewski, Pickrell et al ., and Lin et al . suggest that mapping and sequencing errors and genetic variants led to false discovery of RNA-DNA sequence differences in our paper. We repeated our analysis using two different sequence alignment methods and carried out additional experiments including whole genome DNA sequencing. The results are consistent with our finding of widespread RNA-DNA sequence differences.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1210419