A blend hydrogel based on polyoxometalate for long-term and repeatedly localized antibacterial application study

• Published in: International journal of pharmaceutics Vol. 591; p. 119990
• Main Authors: Fang, Yan, Liu, Taiyu, Xing, Cuili, Chang, Jiangnan, Li, Mingxue
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.12.2020
• Subjects: Antibacterial effect; Hydrogel material; Practical application; Putative mechanism analysis; Putative mechanism analysis; Practical application; Hydrogel material; Antibacterial effect
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2020.119990

Blend hydrogel based on polyoxometalate was demonstrated to be endowed with the superior characteristics of hydrogel along with excellent bactericidal effect of polyoxometalate. [Display omitted] •A polyoxometalate-based blend hydrogel system was successfully constructed.•The physicochemical properties and antibacterial activity of the blend system were fully characterized.•The blend hydrogel exhibited long-term and repeatedly localized bactericidal effect.•The practical applications along with future prospects in relevant areas were investigated and forecasted.•This work might offer probable ways to reduce the antibiotic dosage. Herein, a polyoxometalate (POM)-based blend hydrogel system was in situ constructed by incorporating cetyltrimethylammoniumbromide (CTAB)-encapsulated POM cationic micelles to bare hydrogel matrixes followed by copolymerization of multivalent crosslinking groups. It was demonstrated that the fabricated blend hydrogel possessed tunable physicochemical properties, good swelling behavior (maximum swelling rate of 229% in buffer solution of pH 8.0), excellent local action and sustained release of POM component (release ratio achieved nearly 100% at the time of 120 min). Antibacterial activity study revealed that the introduction of POM greatly improved the bioavailability of itself, namely, leading to a more effective enhancement of therapeutic effects (survival ratio of both strains less than 5%). Besides, bactericidal rates (ca. 51%) were achieved even after six runs repeated, thereby verifying the biological application potential of this material. Finally, the practical application potentials were investigated and future prospects in relevant research areas were forecasted.