Synthesis of novel azasugar-containing 2'β-C-Me 9-deaza nucleosides as potential anti-hepatitis C virus agents

As a part of our ongoing discovery efforts exploring azasugar as agents for treating various unmet medical needs, we prepared analogs of azasugar as potential anti-hepatitis C virus (HCV) agents. Herein we describe the synthesis of novel 2'β-C-Me 9-deazanucleoside azasugar analogs.

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Bibliographic Details
Published inNucleosides, nucleotides & nucleic acids Vol. 42; no. 4; pp. 317 - 327
Main Authors Kotian, Pravin L., Wu, Minwan, Ghosh, Ajit, Polach, Kevin J., El-Kattan, Yahya, Kumar, V. Satish, Lin, Tsu-Hsing, Cheng, Xiaogang, Bantia, Shanta, Raman, Krishnan, Chand, Pooran, Babu, Yarlagadda S.
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis 2023
Taylor & Francis Ltd
Subjects
antiviral
Antiviral Agents
azasugar
Biochemistry & Molecular Biology
C-nucleoside
HCV
Hepacivirus
Hepatitis C
Hepatitis C - drug therapy
Humans
Imino sugar
Life Sciences & Biomedicine
Nucleosides
RNA polymerase
Science & Technology
RNA REPLICATION
RNA polymerase
SUGAR
INHIBITION
THERAPY
REDUCTION
Imino sugar
azasugar
STRUCTURAL BASIS
antiviral
HCV
RIBONUCLEOSIDES
C-nucleoside
DERIVATIVES
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Summary:As a part of our ongoing discovery efforts exploring azasugar as agents for treating various unmet medical needs, we prepared analogs of azasugar as potential anti-hepatitis C virus (HCV) agents. Herein we describe the synthesis of novel 2'β-C-Me 9-deazanucleoside azasugar analogs.
Bibliography:ObjectType-Article-1
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ISSN:1525-7770
1532-2335
DOI:10.1080/15257770.2022.2142609