Fibrinolytic system and reproductive process with special reference to fibrinolytic failure in pre-eclampsia

Here we summarize the recent progress in research on the role of the fibrinolytic system in reproduction, with a special emphasis on the role of the plasminogen activator inhibitors in fetal development. Trophoblasts produce fibrinolytic proteins that can promote normal implantation and regulate blo...

Full description

Saved in:
Bibliographic Details
Published inHuman reproduction (Oxford) Vol. 10 Suppl 2; p. 121
Main Authors Gilabert, J, Estellés, A, Grancha, S, España, F, Aznar, J
Format Journal Article
LanguageEnglish
Published England 01.12.1995
Subjects
Online AccessGet more information

Cover

Loading…
More Information
Summary:Here we summarize the recent progress in research on the role of the fibrinolytic system in reproduction, with a special emphasis on the role of the plasminogen activator inhibitors in fetal development. Trophoblasts produce fibrinolytic proteins that can promote normal implantation and regulate blood flow to the fetus and placenta throughout pregnancy. Normal pregnancy is associated with a hypofibrinolytic state that is fundamentally caused by an increase in plasminogen activator inhibitors types 1 and 2. In pre-eclampsia, a fibrinolytic failure, resulting from an increase in plasma and placental concentrations of plasminogen activator inhibitor-1, was observed. The localized elevated concentrations of placenta plasminogen activator inhibitor-1 protein and mRNA observed in pre-eclamptic patients would be expected to foster the deposition of fibrin and thus play a role in the complications associated with this disease. The decreased plasminogen activator inhibitor-2 concentrations in placenta and plasma from intrauterine fetal growth retardation pregnancies and the positive correlation between plasma/placenta plasminogen activator inhibitor-2 concentration and birthweight suggest that this inhibitor could be considered an adequate marker of placental function.
ISSN:0268-1161
DOI:10.1093/humrep/10.suppl_2.121