Genetic analysis of chromosomal region 97D2-9 of Drosophila melanogaster

The rough homeobox gene of D. melanogaster is required for the correct patterning of the developing eye. The locus maps to cytological location 97D2-5, a region which has not been extensively characterised. As part of our genetic and molecular characterization of rough we carried out an EMS mutagene...

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Bibliographic Details
Published inMolecular & general genetics Vol. 239; no. 1-2; p. 109
Main Authors Knibb, W R, Tearle, R G, Elizur, A, Saint, R
Format Journal Article
LanguageEnglish
Published Germany 01.05.1993
Subjects
Animals
Cell Cycle Proteins
Chromosomes - ultrastructure
Crosses, Genetic
DNA-Binding Proteins - genetics
Drosophila melanogaster - genetics
Drosophila Proteins
Eye - embryology
Female
Genes, Homeobox
Genetic Complementation Test
In Situ Hybridization
Male
Microscopy, Electron, Scanning
Microtubule-Associated Proteins
Mutagenesis
Transcription Factors - genetics
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Summary:The rough homeobox gene of D. melanogaster is required for the correct patterning of the developing eye. The locus maps to cytological location 97D2-5, a region which has not been extensively characterised. As part of our genetic and molecular characterization of rough we carried out an EMS mutagenesis to generate mutants that map to the surrounding region, 97D2-9 which is deleted in Df(3R)ro-XB3. We have generated 1 visible and 13 lethal mutations which, together with the previously described Toll and ms(3)K10 loci, and other unpublished lethals, define nine complementation groups--four lethal, three semi-lethal, one visible and one male-sterile. In addition to rough, one other locus within this region, 1(3)97De, was shown to be required for formation of the normal pattern of photoreceptor cells in the compound eye.
ISSN:0026-8925
DOI:10.1007/BF00281608