Individual resistance to cerebral ischemia and negative effect of emotional stress on the course of this disorder

The ratio of low-activity and high-activity rats differed in autumn, winter, and spring litters. Initially more intensive cerebral blood flow in low-active rats and its more pronounced decrease after common carotid artery occlusion determined their higher sensitivity to cerebral ischemia (compared t...

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Published inBulletin of experimental biology and medicine Vol. 137; no. 2; pp. 124 - 127
Main Authors Gannushkina, I V, Koplik, E V, Konorova, I L, Antelava, A L, Pirogova, G V
Format Journal Article
LanguageEnglish
Russian
Published United States Springer Nature B.V 01.02.2004
Subjects
Animals
Brain Ischemia - etiology
Brain Ischemia - physiopathology
Brain Ischemia - prevention & control
Brain Ischemia - psychology
Cerebrovascular Circulation
Collateral Circulation
Electroencephalography
Immobilization
Male
Rats
Rats, Wistar
Seasons
Stress, Psychological - complications
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Summary:The ratio of low-activity and high-activity rats differed in autumn, winter, and spring litters. Initially more intensive cerebral blood flow in low-active rats and its more pronounced decrease after common carotid artery occlusion determined their higher sensitivity to cerebral ischemia (compared to high-activity animals). After 18-h immobilization stress cerebral blood flow decreased by 10-15%, which abolished the difference in the individual resistance to cerebral ischemia. Independently on emotional resistance, cerebral ischemia was not accompanied by the development of collateral blood flow in the acute period and caused death of 90% rats.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
1573-8221
DOI:10.1023/B:BEBM.0000028119.46097.1a