Clinical utility of miRNA-1, miRNA-29g and miRNA-133s plasma levels in prostate cancer patients with high-intensity training after androgen-deprivation therapy

The randomized trials showed that the addition of training resistance program to androgen-deprivation therapy (ADT) had many beneficial effects for prostate cancer (PC) patients (significant protective effect on the volume of muscle mass) and the studies have revealed a panel of miRNAs, which are de...

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Published inPhysiological research Vol. 68; no. Suppl 2; pp. S139 - S147
Main Authors Gazova, A, Samakova, A, Laczo, E, Hamar, D, Polakovicova, M, Jurikova, M, Kyselovic, J
Format Journal Article
LanguageEnglish
Published Czech Republic Institute of Physiology 01.01.2019
Subjects
Aged
Androgen Antagonists - therapeutic use
Androgens
Biomarkers
Body composition
Bone density
Clinical trials
Consent
Exercise
Fitness training programs
Humans
Insulin
Interleukin 6
Male
Metabolism
MicroRNAs
MicroRNAs - blood
Middle Aged
miRNA
Muscle strength
Patients
Physical education
Physical fitness
Physical training
Plasma levels
Prospective Studies
Prostate cancer
Prostatic Neoplasms - blood
Prostatic Neoplasms - therapy
Resistance Training
Serum levels
Sports training
Strength training
Studies
Testosterone
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Summary:The randomized trials showed that the addition of training resistance program to androgen-deprivation therapy (ADT) had many beneficial effects for prostate cancer (PC) patients (significant protective effect on the volume of muscle mass) and the studies have revealed a panel of miRNAs, which are deregulate in PC and may serve as promising biomarkers of PC risk. The primary aim of our present study was to investigate the effect of exercise training to changes in body composition (muscle strength) and the secondary endpoint was to investigate the impact of an exercise training program on plasma levels of selected myogenic microRNAs (miRNAs) (miRNA-1, miRNA-29b, and miRNA-133) in PC patients undergoing the ADT. Effect of ADT and exercise intervention showed significant increase (experimental group vs. control group) the changes in body composition, free testosterone levels, IL-6 and plasma levels of myogenic miRNAs and significant reduced insulin serum levels. In conclusion, resistance training with ADT in the treatment of PC significantly changed the physical and metabolic function and the plasma levels of specific myogenic miRNAs. Our data support with the other publicized results.
ISSN:0862-8408
1802-9973
DOI:10.33549/PHYSIOLRES.934298