Hypoxylonone, a new oxa-bridged seven-membered ring analog from fungus Hypoxylon cf. subgilvum SWUF15-004

A new oxa-bridged seven-membered ring analog, hypoxylonone (1), and thirteen known compounds (2-14) were isolated from fungus Hypoxylon cf. subgilvum SWUF15-004. The structures were elucidated by the analysis of spectroscopic (IR, 1 D and 2 D NMR), HRESIMS and X-ray diffraction (MoKα) data. Several...

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Published inNatural product research Vol. 38; no. 3; pp. 415 - 422
Main Authors Jantaharn, Phongphan, Mongkolthanaruk, Wiyada, Suwannasai, Nuttika, Senawong, Thanaset, Boonmak, Jaursup, Youngme, Sujittra, McCloskey, Sirirath
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 2024
Taylor & Francis Ltd
Subjects
8-oxabicyclo[3.2.1]octane
Animals
Ascomycota - chemistry
Cytotoxicity
Fungi
HeLa Cells
Humans
Hypoxylon cf. subgilvum
Mice
Molecular Structure
Nitric oxide
NMR
Nuclear magnetic resonance
oxa-bridged seven-membered ring
RAW 264.7 Cells
Toxicity
Tumor cell lines
X-ray diffraction
Hypoxylon cf. subgilvum
cytotoxicity
oxa-bridged seven-membered ring
8-oxabicyclo[3.2.1]octane
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Summary:A new oxa-bridged seven-membered ring analog, hypoxylonone (1), and thirteen known compounds (2-14) were isolated from fungus Hypoxylon cf. subgilvum SWUF15-004. The structures were elucidated by the analysis of spectroscopic (IR, 1 D and 2 D NMR), HRESIMS and X-ray diffraction (MoKα) data. Several isolated compounds were evaluated for cytotoxicity against four human cancer cell lines (HeLa, HT29, MCF-7, A549). Compound 1 exhibited weak inhibitory effects of the nitric oxide production in RAW264.7 cells. Compounds 8 and 9 exhibited slight cytotoxicity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2125968