Proving paternity of children with deceased fathers

Determination of paternity was attempted in the case of three children whose putative fathers are dead using DNA samples of the paternal grandparents. The DNA analyses were performed with both multilocus and single-locus probes which resolve highly polymorphic areas of human genome. The results were...

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Bibliographic Details
Published inHuman genetics Vol. 87; no. 6; p. 657
Main Authors Helminen, P, Johnsson, V, Ehnholm, C, Peltonen, L
Format Journal Article
LanguageEnglish
Published Germany 01.10.1991
Subjects
Blood Group Antigens
Blotting, Southern
Child
DNA Probes
Female
Humans
Male
Paternity
Polymorphism, Genetic
Repetitive Sequences, Nucleic Acid
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Summary:Determination of paternity was attempted in the case of three children whose putative fathers are dead using DNA samples of the paternal grandparents. The DNA analyses were performed with both multilocus and single-locus probes which resolve highly polymorphic areas of human genome. The results were conclusive with both types of probes and facilitated, for example, the exclusion of the brother of the putative father. The evidence for true paternity obtained with DNA analyses can be considered reliable in this type of "indirect" paternity in which tests based on protein polymorphism are inconclusive.
ISSN:0340-6717
DOI:10.1007/BF00201720