A Comparison of Consumption and Recovery Profiles According to Anaesthetic Circuit Mode using a New Multifunctional Closed-Circuit Anaesthesia System during Desflurane Anaesthesia: A Clinical Study

• Published in: Journal of international medical research Vol. 38; no. 1; pp. 160 - 168
• Main Authors: Park, JY, Shin, HW, Jeon, SK, Choi, SU, Kim, WY, Lee, HW, Lim, HJ, Yoon, SM, Chang, SH
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2010
• Subjects: Adult; Anesthesia, Closed-Circuit - instrumentation; Anesthetics, Inhalation - administration & dosage; Drug Delivery Systems; Female; Gynecologic Surgical Procedures; Hemodynamics; Humans; Isoflurane - administration & dosage; Isoflurane - analogs & derivatives; Middle Aged; Single-Blind Method; Wakefulness - drug effects; Closed circuit anaesthesia; Anaesthesia consumption; Desflurane; Fresh gas flow; Semi-closed circuit; anaesthesia
• ISSN: 0300-0605; 1473-2300
• DOI: 10.1177/147323001003800118

This clinical study compared induction time, consumed anaesthetic dose, and haemodynamic and recovery profiles when using a new type of multifunctional anaesthesia machine (Zeus®) in semi-closed or closed circuit modes. Sixty female patients undergoing gynaecological surgery were randomly assigned to three groups and received desflurane anaesthesia through a semi-closed circuit (SCC) at fresh gas flow rates of 4 l/min (SCC 4 l/min) or 2 l/min (SCC 2 l/min), or through a closed circuit (CC). Anaesthesia was maintained at the minimum alveolar concentration for blocking the adrenergic response to painful stimulus (MACBAR) (4.6% end-tidal desflurane) during each operation. The time required to reach MACBAR was significantly shorter and the dose of desflurane was significantly smaller in the CC group compared with the other groups. There were no differences in haemodynamic and recovery profiles between the groups. It is concluded that the CC mode allowed a faster and more reliable induction, lower anaesthetic consumption and stable haemodynamic and recovery profiles.