Failure of calcitriol treatment in a patient with malignant osteopetrosis

In an attempt to stimulate bone resorption, a 10-week-old infant with malignant infantile osteopetrosis was treated with high doses of calcitriol, a potent bone resorption stimulatory agent, combined with a low calcium diet to prevent hypercalcaemia. Although calcitriol administration was initiated...

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Bibliographic Details
Published inEuropean journal of pediatrics Vol. 152; no. 10; p. 818
Main Authors van Lie Peters, E M, Aronson, D C, Everts, V, Dooren, L J
Format Journal Article
LanguageEnglish
Published Germany 01.10.1993
Subjects
Bone and Bones - pathology
Calcitriol - therapeutic use
Female
Humans
Infant
Osteopetrosis - congenital
Osteopetrosis - drug therapy
Osteopetrosis - metabolism
Osteopetrosis - pathology
Parathyroid Hormone - blood
Treatment Failure
Vitamin D - metabolism
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Summary:In an attempt to stimulate bone resorption, a 10-week-old infant with malignant infantile osteopetrosis was treated with high doses of calcitriol, a potent bone resorption stimulatory agent, combined with a low calcium diet to prevent hypercalcaemia. Although calcitriol administration was initiated at this very young age, our patient did not show any clinical, radiological, or histological improvement. Despite reports of positive results of this treatment in the literature, our patient did not reveal any signs of bone resorption. She eventually died from the complications of osteopetrosis at the age of 6 months after 88 days of therapy.
ISSN:0340-6199
DOI:10.1007/BF02073378