The activity of different extracts from Panax quinquefolium L. cultures against pathogenic Staphylococcus aureus with respect to ginsenoside content
Ginsenosides can be isolated from various cultures of Panax quinquefolium L., American ginseng. The aim of the study was to determine the antibacterial activity of extracts from leaves, stalks, hairy root cultures and field roots of P. quinquefolium L. containing ginsenosides against Staphylococcus...
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Published in | Archives of biological sciences Vol. 67; no. 4; pp. 1277 - 1284 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
University of Belgrade, University of Novi Sad
2015
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Subjects | |
Online Access | Get full text |
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Summary: | Ginsenosides can be isolated from various cultures of Panax quinquefolium L.,
American ginseng. The aim of the study was to determine the antibacterial
activity of extracts from leaves, stalks, hairy root cultures and field
roots of P. quinquefolium L. containing ginsenosides against Staphylococcus
aureus isolates obtained from various clinical materials. The agar well
diffusion assay was used to evaluate microbial growth inhibition at various
concentrations of extracts. The susceptibility of the clinical isolates to
recommended antibiotics was determined with the disk-diffusion method. The
results showed that the tested extracts inhibited the growth of all S.
aureus clinical isolates, including MRSA (methicillin-resistant S. aureus)
with MIC values ranging from 0.5 mg/mL to 1.7 mg/mL. The level of
antimicrobial activity of extracts depends on the ginsenoside content. Both
field roots and hairy root cultures represent excellent sources of these
metabolites. Extracts with ginsenosides were found to inhibit
multidrug-resistant staphylococci and can be a valuable complement to
antistaphylococcal therapy.
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ISSN: | 0354-4664 1821-4339 |
DOI: | 10.2298/ABS150330104S |