Two new bibenzyl methylglucosides as SIRT3 activators obtained through microbial transformation

Microbial transformation of dihydroresveratrol (DHRSV) using Beauveria bassiana has produced two new methylglucosylated derivatives of DHRSV (1 and 2), whose structures were characterized as 4′-O-(4″-O-methyl-β-D-glucopyranosyl)-dihydroresveratrol (4′-O-MG DHRSV, 1) and 3-O-(4″-O-methyl-β-D-glucopyr...

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Published inJournal of asian natural products research Vol. 26; no. 2; pp. 269 - 279
Main Authors Wang, Yue, Fu, Wei-Cheng, Peng, Yu, Zhang, Ying-Lu, Chen, Jing-Jing, Chen, Tian-Jiao, Yang, Jin-Ling, Gong, Ting, Zhu, Ping
Format Journal Article
LanguageEnglish
Published ABINGDON Taylor & Francis 01.02.2024
Taylor & Francis Ltd
Subjects
Beauveria bassiana
Bibenzyls
Chemistry
Chemistry, Applied
Chemistry, Medicinal
Deacetylation
Life Sciences & Biomedicine
methylglucosylation
microbial transformation
Microorganisms
Molecular docking
Pharmacology & Pharmacy
Physical Sciences
Plant Sciences
Science & Technology
SIRT3 agonist
Beauveria bassiana
Bibenzyls
microbial transformation
methylglucosylation
SIRT3 agonist
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Summary:Microbial transformation of dihydroresveratrol (DHRSV) using Beauveria bassiana has produced two new methylglucosylated derivatives of DHRSV (1 and 2), whose structures were characterized as 4′-O-(4″-O-methyl-β-D-glucopyranosyl)-dihydroresveratrol (4′-O-MG DHRSV, 1) and 3-O-(4″-O-methyl-β-D-glucopyranosyl)-dihydroresveratrol (3-O-MG DHRSV, 2) on the basis of spectroscopic methods. They showed moderate SIRT3 agonistic activity, and compound 2 exhibited the best deacetylation of 406.63% at 10 μM. The activity of 2 increased by 3.12-fold compared with that of DHRSV, since 2 performed better in molecular docking assay (GScore −8.445).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2023.2283483