Determinants of preclinical atherosclerosis are different in type 1 and type 2 diabetic women

• Published in: Physiological research Vol. 65; no. 2; pp. 219 - 228
• Main Authors: Piťhová, P, Štechová, K, Piťha, J, Lánská, V, Kvapil, M
• Format: Journal Article
• Language: English
• Published: Czech Republic Institute of Physiology 01.01.2016
• Subjects: Adult; Age; Age Factors; Atherosclerosis; Atherosclerosis - blood; Atherosclerosis - diagnosis; Atherosclerosis - epidemiology; Blood Glucose - metabolism; Body fat; Body Mass Index; Cardiovascular disease; Cross-Sectional Studies; Diabetes; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - diagnosis; Diabetes Mellitus, Type 1 - epidemiology; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - epidemiology; Disease prevention; Female; Health risk assessment; Humans; Hypertension; Insulin; Insulin resistance; Lipids; Metabolism; Middle Aged; Mortality; Studies; Ultrasonic imaging; Waist-Hip Ratio; Womens health; Young Adult
• ISSN: 0862-8408; 1802-9973
• DOI: 10.33549/physiolres.933019

Diabetes mellitus type 2 ranks among the strongest predictors of cardiovascular diseases (CVD) while the association of type 1 diabetes with CVD is more complex. We studied differences between type 1 and 2 diabetic women regarding association of cardiovascular risk factors with preclinical atherosclerosis expressed as intima-media thickness of common carotid (IMT CCA) and femoral arteries (IMT CFA) measured by high resolution ultrasound. Women with type 1 (n=203) and type 2 diabetes (n=123) were examined with regard to the presence of cardiovascular risk factors. In type 1 diabetic women strong association between IMT CCA and body mass index, waist circumference, and total body fat was found in contrast to type 2 diabetic women. In type 2 diabetic women strong association between IMT CCA and fasting glucose, glycated hemoglobin, and atherogenic index of plasma (log TG/HDL cholesterol) was observed in contrast to type 1 diabetic women. In type 1 diabetic women, IMT CFA was associated with body fat in contrast to type 2 diabetic women. Preclinical atherosclerosis in type 1 diabetic women was strongly associated with factors reflecting body fat and its distribution, while in type 2 diabetic women preclinical atherosclerosis was associated with markers reflecting glucose and lipid metabolic disorders.