Anti-Monomeric C-Reactive Protein Antibody Ameliorates Arthritis and Nephritis in Mice

• Published in: The Journal of immunology (1950) Vol. 207; no. 7; pp. 1755 - 1762
• Main Authors: Fujita, Chitose, Sakurai, Yasuo, Yasuda, Yuki, Takada, Yoshikazu, Huang, Cheng-Long, Fujita, Masaaki
• Format: Journal Article
• Language: English
• Published: 01.10.2021

Conformation-specific Ags are ideal targets for mAb-based immunotherapy. Here, we demonstrate that the monomeric form of C-reactive protein (mCRP) is a specific therapeutic target for arthritis and nephritis in a murine model. Screening of >1800 anti-mCRP mAb clones identified 3C as a clone recog...