Anti-Monomeric C-Reactive Protein Antibody Ameliorates Arthritis and Nephritis in Mice

Conformation-specific Ags are ideal targets for mAb-based immunotherapy. Here, we demonstrate that the monomeric form of C-reactive protein (mCRP) is a specific therapeutic target for arthritis and nephritis in a murine model. Screening of >1800 anti-mCRP mAb clones identified 3C as a clone recog...

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Published inThe Journal of immunology (1950) Vol. 207; no. 7; pp. 1755 - 1762
Main Authors Fujita, Chitose, Sakurai, Yasuo, Yasuda, Yuki, Takada, Yoshikazu, Huang, Cheng-Long, Fujita, Masaaki
Format Journal Article
LanguageEnglish
Published 01.10.2021
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Summary:Conformation-specific Ags are ideal targets for mAb-based immunotherapy. Here, we demonstrate that the monomeric form of C-reactive protein (mCRP) is a specific therapeutic target for arthritis and nephritis in a murine model. Screening of >1800 anti-mCRP mAb clones identified 3C as a clone recognizing the monomeric, but not polymeric, form of CRP. The anti-mCRP mAb suppressed leukocyte infiltration in thioglycollate-induced peritonitis, attenuated rheumatoid arthritis symptoms in collagen Ab-induced arthritis model mice, and attenuated lupus nephritis symptoms in MRL/Mp-lpr/lpr lupus-prone model mice. These data suggest that the anti-mCRP mAb 3C has therapeutic potential against rheumatoid arthritis and lupus nephritis.
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ISSN:0022-1767
1550-6606
1550-6606
DOI:10.4049/jimmunol.2100349