Palladium-Catalyzed Benzodiazepines Synthesis

This review is focused on palladium-catalyzed reactions as efficient strategies aimed at the synthesis of different classes of benzodiazepines. Several reaction typologies are reported including hydroamination, amination, C–H arylation, N-arylation, and the Buchwald–Hartwig reaction, depending on th...

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Bibliographic Details
Published inCatalysts Vol. 10; no. 6; p. 634
Main Authors Christodoulou, Michael S., Beccalli, Egle M., Giofrè, Sabrina
Format Journal Article
LanguageEnglish
Published MDPI AG 01.06.2020
Subjects
benzodiazepine
cyclization
domino process
intramolecular Buchwald–Hartwig
N-arylation
Pd-catalysis
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Summary:This review is focused on palladium-catalyzed reactions as efficient strategies aimed at the synthesis of different classes of benzodiazepines. Several reaction typologies are reported including hydroamination, amination, C–H arylation, N-arylation, and the Buchwald–Hartwig reaction, depending on the different substrates identified as halogenated starting materials (activated substrates) or unactivated unsaturated systems, which then exploit Pd(0)- or Pd(II)-catalytic species. In particular, the use of the domino reactions, as intra- or intermolecular processes, are reported as an efficient and eco-compatible tool to obtain differently functionalized benzodiazepines. Different domino reaction typologies are the carboamination, aminoarylation, aminoacethoxylation, aminohalogenation, and aminoazidation.
ISSN:2073-4344
2073-4344
DOI:10.3390/catal10060634