Evolution and sequence analysis of a human Y-chromosomal DNA fragment

A Y-chromosomal DNA fragment has been isolated from a human Y-Charon 21A recombinant library. Evolutionary analysis of 1F5 indicates that the size and sequence of this fragment have been conserved in higher primates. Deletion mapping and in situ hybridization analysis have localized 1F5 to the middl...

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Bibliographic Details
Published inJournal of molecular evolution Vol. 33; no. 2; p. 133
Main Authors Whisenant, E C, Rasheed, B K, Ostrer, H, Bhatnagar, Y M
Format Journal Article
LanguageEnglish
Published Germany 01.08.1991
Subjects
Base Sequence
Biological Evolution
Blotting, Southern
Chromosome Deletion
Chromosome Mapping
DNA
Female
Humans
Karyotyping
Male
Molecular Sequence Data
Nucleic Acid Hybridization
Y Chromosome
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Summary:A Y-chromosomal DNA fragment has been isolated from a human Y-Charon 21A recombinant library. Evolutionary analysis of 1F5 indicates that the size and sequence of this fragment have been conserved in higher primates. Deletion mapping and in situ hybridization analysis have localized 1F5 to the middle euchromatic portion of the long arm of the human Y chromosome at Yq11.2. Sequence analysis revealed the presence of an atypical Alu element and two regions rich in polypyrimidine-polypurine residues.
ISSN:0022-2844
DOI:10.1007/BF02193627