Effects of mannitol and steroid therapy on intracranial volume-pressure relationships in patients
The intracranial volume-pressure response was measured in 61 patients undergoing continous monitoring of intraventicular pressure. This test, which determlnes the increase in intracranial pressure induced by an addition of 1 ml in ventricular CSF volume in 1 sencond, yields information concerning sp...
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Published in | Journal of neurosurgery Vol. 42; no. 3; p. 274 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
01.03.1975
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Subjects | |
Online Access | Get more information |
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Summary: | The intracranial volume-pressure response was measured in 61 patients undergoing continous monitoring of intraventicular pressure. This test, which determlnes the increase in intracranial pressure induced by an addition of 1 ml in ventricular CSF volume in 1 sencond, yields information concerning spatial compensation in patients with intracranial space-occupying processes. On the basis of variability tests, a change in volume-pressure response of 2 mm Hg/ml was accepted as significant. Pronounced enlargement of the ventricles interferes with the test. In patients with intracranial hypertension, intravenous mannitol (0.5gm/kg) and intramuscular betamethasone (26 mg) both reduce the volume-pressure response significantly more than they reduce intracranial pressure. This suggests that these agents favorably alter the configuration of the volume-pressure curve. |
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ISSN: | 0022-3085 |
DOI: | 10.3171/jns.1975.42.3.0274 |