Mapping the mutation causing the X-linked lymphoproliferative syndrome in relation to restriction fragment length polymorphisms on Xq

• Published in: Human genetics Vol. 82; no. 4; p. 349
• Main Authors: Skare, J C, Sullivan, J L, Milunsky, A
• Format: Journal Article
• Language: English
• Published: Germany 01.07.1989
• Subjects: Chromosome Mapping; Female; Genetic Linkage; Humans; Lymphoproliferative Disorders - genetics; Male; Mutation; Pedigree; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Recombination, Genetic; Syndrome; X Chromosome

The X-linked lymphoproliferative syndrome (XLP) results in fatal infectious mononucleosis, hypogamma-globulinemia, and malignant lymphoma. The mutation has been mapped relative to several restriction fragment length polymorphism (RFLP) markers in the Xq21-Xq27 vicinity. The DXS37 locus was found to...