Mapping the mutation causing the X-linked lymphoproliferative syndrome in relation to restriction fragment length polymorphisms on Xq

The X-linked lymphoproliferative syndrome (XLP) results in fatal infectious mononucleosis, hypogamma-globulinemia, and malignant lymphoma. The mutation has been mapped relative to several restriction fragment length polymorphism (RFLP) markers in the Xq21-Xq27 vicinity. The DXS37 locus was found to...

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Bibliographic Details
Published inHuman genetics Vol. 82; no. 4; p. 349
Main Authors Skare, J C, Sullivan, J L, Milunsky, A
Format Journal Article
LanguageEnglish
Published Germany 01.07.1989
Subjects
Chromosome Mapping
Female
Genetic Linkage
Humans
Lymphoproliferative Disorders - genetics
Male
Mutation
Pedigree
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Recombination, Genetic
Syndrome
X Chromosome
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Summary:The X-linked lymphoproliferative syndrome (XLP) results in fatal infectious mononucleosis, hypogamma-globulinemia, and malignant lymphoma. The mutation has been mapped relative to several restriction fragment length polymorphism (RFLP) markers in the Xq21-Xq27 vicinity. The DXS37 locus was found to be near both the DXS42 and XLP loci.
ISSN:0340-6717
DOI:10.1007/BF00273996