Genome Sequencing of Multiple Isolates Highlights Subtelomeric Genomic Diversity within Fusarium fujikuroi

Comparisons of draft genome sequences of three geographically distinct isolates of Fusarium fujikuroi with two recently published genome sequences from the same species suggest diverse profiles of secondary metabolite production within F. fujikuroi. Species- and lineage-specific genes, many of which...

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Published inGenome biology and evolution Vol. 7; no. 11; pp. 3062 - 3069
Main Authors Chiara, Matteo, Fanelli, Francesca, Mulè, Giuseppina, Logrieco, Antonio F, Pesole, Graziano, Leslie, John F, Horner, David S, Toomajian, Christopher
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.11.2015
Subjects
Adaptation, Physiological - genetics
DNA, Fungal - genetics
Evolution, Molecular
Fusarium - genetics
Gene Duplication
Gene Transfer, Horizontal
Genetic Variation
Genetics, Population
Genome Report
Genome, Fungal
Genomics
Host-Pathogen Interactions - genetics
Multigene Family
Phylogeny
Sequence Analysis, DNA
mycotoxin
comparative genomics
secondary metabolites
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Summary:Comparisons of draft genome sequences of three geographically distinct isolates of Fusarium fujikuroi with two recently published genome sequences from the same species suggest diverse profiles of secondary metabolite production within F. fujikuroi. Species- and lineage-specific genes, many of which appear to exhibit expression profiles that are consistent with roles in host-pathogen interactions and adaptation to environmental changes, are concentrated in subtelomeric regions. These genomic compartments also exhibit distinct gene densities and compositional characteristics with respect to other genomic partitions, and likely play a role in the generation of molecular diversity. Our data provide additional evidence that gene duplication, divergence, and differential loss play important roles in F. fujikuroi genome evolution and suggest that hundreds of lineage-specific genes might have been acquired through horizontal gene transfer.
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Data deposition: This project has been deposited at GenBank under the accessions: JRVH00000000 (Fusarium fujikuroi KSU 3368), JRVG00000000 (F. fujikuroi KSU X-10626), and JRVF00000000 (F. fujikuroi FGSC 8932).
These authors contributed equally to this work.
Associate editor: Rachel O’Neill
ISSN:1759-6653
1759-6653
DOI:10.1093/gbe/evv198