Hipposponols A and B, two new 9, 11-secosterols from the marine sponge Hippospongia lachne de Laubenfels

• Published in: Natural product research Vol. 38; no. 15; pp. 2562 - 2568
• Main Authors: Ding, Ya-Fang, Liu, Li-Yun, Tang, Jie, Fan, Dong-Xue, Ji, Yuan-Yuan, Lin, Hou-Wen, Wang, Jie, Hong, Li-Li
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.08.2024; Taylor & Francis Ltd
• Subjects: Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Cell Line, Tumor; Cytotoxicity; Drug Screening Assays, Antitumor; Hippospongia lachne; Hippospongia lachne de Laubenfels; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Marine sponge; Molecular Structure; NMR; Nuclear magnetic resonance; Porifera - chemistry; secosterol; Toxicity; Marine sponge; Hippospongia lachne de Laubenfels; secosterol; cytotoxicity
• ISSN: 1478-6419; 1478-6427; 1478-6427
• DOI: 10.1080/14786419.2023.2188588

Two new 9,11-secosterols, hipposponols A (1) and B (2), together with five known analogues, aplidiasterol B (3), (3β,5α,6β)-3,5,6-triol-cholest-7-ene (4), (3β,5α,6β,22E)-3,5,6-triol-ergosta-7,22-diene (5), and one pair of inseparable C-24 epimers of (3β,5α,6β,22E)-3,5,6-triol-stigmasta-7,22-diene (6/7), were isolated from the marine sponge Hippospongia lachne de Laubenfels. The structures of isolated compounds were extensively elucidated based on HRESIMS and NMR data. Compounds 2 − 5 showed cytotoxicity against PC9 cells with IC 50 values ranging from 34.1 ± 0.9 to 38.9 ± 1.0 µM and compound 4 displayed cytotoxicity against MCF-7 cells with IC 50 value of 39.0 ± 0.4 µM.