Two new oleanane triterpenes from Maytenus hookeri

Two new triterpenes mayteneri A (1), mayteneri B (2), and seven known compounds (3-9) were isolated from stems of Maytenus hookeri Loes. The chemical structures of compounds 1 and 2 were established by 1D, 2D NMR, HRESIMS analysis, and calculating electronic circular dichroism (ECD). The structures...

Full description

Saved in:
Bibliographic Details
Published inJournal of asian natural products research Vol. 26; no. 7; pp. 803 - 811
Main Authors Yang, Quan-Yu, Yang, Song-Xue, Wei, Qiong, Ma, Yan-Zi, Li, Bo, Wu, Xue-Wen, Zhang, Rui-Han, Zhang, Xing-Jie, Li, Xiao-Li, Xiao, Wei-Lie
Format Journal Article
LanguageEnglish
Published ABINGDON Taylor & Francis 09.05.2024
Taylor & Francis Ltd
Subjects
anti-inflammatory activity
Celastraceae
chemical composition
Chemical compounds
Chemistry
Chemistry, Applied
Chemistry, Medicinal
Circular dichroism
Dichroism
Inflammasomes
Life Sciences & Biomedicine
Maytenus
Maytenus hookeri
NMR
Nuclear magnetic resonance
Pharmacology & Pharmacy
Physical Sciences
Plant Sciences
Science & Technology
Triterpenes
Two dimensional analysis
SESQUITERPENE ALKALOIDS
ACID
Celastraceae
triterpenes
Maytenus hookeri
MEDICINE
chemical composition
anti-inflammatory activity
Online AccessGet full text

Cover

More Information
Summary:Two new triterpenes mayteneri A (1), mayteneri B (2), and seven known compounds (3-9) were isolated from stems of Maytenus hookeri Loes. The chemical structures of compounds 1 and 2 were established by 1D, 2D NMR, HRESIMS analysis, and calculating electronic circular dichroism (ECD). The structures of known compounds 3-9 were determined by comparison of their spectral with those reported. Compounds 4-7 showed significant inhibitory activity for NLRP3 inflammasome, with the IC 50 values of 2.36-3.44 μM.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2024.2340073