Identification by GC/MS of 6-monoacetylmorphine as an indicator of heroin abuse

A capillary gas chromatography mass spectrometry assay has been developed for the determination of 6-monoacetylmorphine in human urine, which is a confirmatory marker of heroin abuse. It was extracted with chloroform-isopropanol-n-heptane (50:17:33, v/v) from alkalinized samples (pH 9.2), using leva...

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Bibliographic Details
Published inEuropean journal of clinical pharmacology Vol. 37; no. 5; p. 531
Main Authors Kintz, P, Mangin, P, Lugnier, A A, Chaumont, A J
Format Journal Article
LanguageEnglish
Published Germany 01.01.1989
Subjects
Acetylation
Gas Chromatography-Mass Spectrometry
Heroin Dependence - urine
Humans
Morphine Derivatives - urine
Street Drugs - analysis
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Summary:A capillary gas chromatography mass spectrometry assay has been developed for the determination of 6-monoacetylmorphine in human urine, which is a confirmatory marker of heroin abuse. It was extracted with chloroform-isopropanol-n-heptane (50:17:33, v/v) from alkalinized samples (pH 9.2), using levallorphan as the internal standard. After derivatization with trifluoroacetic anhydride, the drugs were separated on a 25-m capillary column BP 10 and detected by selected ion monitoring.
ISSN:0031-6970
DOI:10.1007/BF00558138