Natural products in drug discovery: meeting the urgency for new antimicrobials for human and veterinary use

The scenario of growing microbial resistance and of lack of interest of pharmaceutical companies in developing new antimicrobial drugs jeopardizes the present and the future of the treatment of infectious diseases. Different approaches such as antimicrobial peptides and CRISP-R have been explored to...

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Bibliographic Details
Published inAIMS molecular science Vol. 10; no. 1; pp. 11 - 21
Main Authors Dias-Souza, Marcus Vinícius, Perpétuo, Arthur Azevedo, dos Santos, Gabriel Souza, Machado, Luiz Felipe Carreiro, dos Santos, Renan Martins
Format Journal Article
LanguageEnglish
Published AIMS Press 01.01.2023
Subjects
antimicrobial
bacteria
molecular targets
pharmacology
phytoextracts
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Summary:The scenario of growing microbial resistance and of lack of interest of pharmaceutical companies in developing new antimicrobial drugs jeopardizes the present and the future of the treatment of infectious diseases. Different approaches such as antimicrobial peptides and CRISP-R have been explored to manage this situation, however, they have important limitations such as their high cost. Natural products comprise complex molecular structures for which reports of bacterial resistance are rare. They present specific and/or unspecific mechanisms of action that can be explored to provide safe and effective management of infectious diseases. In this review we assessed phytoextracts with evidence of their benefits for treating infectious diseases in humans and animals, towards the use of data for clinical and experimental purposes. Mechanisms of bacterial resistance to antimicrobials are also discussed.
ISSN:2372-0301
2372-0301
DOI:10.3934/molsci.2023002