Emerging targets for positron emission tomography imaging in proteinopathies

Positron emission tomography (PET) imaging of neurodegenerative disease has historically focused on a small number of established targets. The development of selective PET radiotracers for novel biological targets enables new ways to interrogate the neuropathology of proteinopathies and will advance...

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Bibliographic Details
Published inNpj imaging Vol. 2; no. 1; pp. 30 - 7
Main Authors Chassé, Melissa, Vasdev, Neil
Format Journal Article
LanguageEnglish
Published Switzerland Nature Publishing Group 01.01.2024
Nature Publishing Group UK
Nature Portfolio
Subjects
Alzheimer's disease
Biomarkers
Brain research
Clinical trials
Enzymes
FDA approval
Huntingtons disease
Kinetics
Ligands
Neurodegeneration
Neurosciences
Pharmaceutical sciences
Proteins
Tomography
Imaging techniques
Brain imaging
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Summary:Positron emission tomography (PET) imaging of neurodegenerative disease has historically focused on a small number of established targets. The development of selective PET radiotracers for novel biological targets enables new ways to interrogate the neuropathology of proteinopathies and will advance our understanding of neurodegeneration. This perspective aims to highlight recent PET radiotracers developed for five emerging targets in proteinopathies (i.e., mHTT, BACE1, TDP-43, OGA, and CH24H).
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ISSN:2948-197X
2948-197X
DOI:10.1038/s44303-024-00032-4