Differentiating amorphous mixtures of cefuroxime axetil and copovidone by X-ray diffraction and differential scanning calorimetry

• Published in: Annales pharmaceutiques françaises Vol. 72; no. 2; p. 95
• Main Authors: Nicolaï, B, Perrin, M-A, Céolin, R, Rietveld, I B
• Format: Journal Article
• Language: English
• Published: France 01.03.2014
• Subjects: Anti-Bacterial Agents - chemistry; Calorimetry; Calorimetry, Differential Scanning; Cefuroxime - analogs & derivatives; Cefuroxime - chemistry; Pharmaceutic Aids - chemistry; Povidone - chemistry; X-Ray Diffraction; Ordre local; Dispersion solide; Active pharmaceutical ingredient–excipient interaction; Solid dispersion; Interaction principe actif–excipient; Local order; État amorphe; Amorphous state; Vitreous state; État vitreux
• ISSN: 0003-4509
• DOI: 10.1016/j.pharma.2013.11.004

The amorphous, molecular solid dispersion of cefuroxime axetil and copovidone with the mass ratio 71/29 is compared to its pure components in the amorphous state and to an amorphous mechanical mixture with the same mass ratio. Calorimetric studies demonstrate that all these materials are vitreous. By using X-ray diffraction profiles, a clear difference can be observed between the local order of the solid dispersion and that of the mechanical mixture. More generally, it is shown how the presence or absence of additivity in the diffraction data can be used to distinguish between different amorphous mixtures.