A meta-analysis of the effect of oral and inhaled corticosteroids on growth

• Published in: Journal of allergy and clinical immunology Vol. 93; no. 6; pp. 967 - 976
• Main Authors: Allen, David B., Mullen, MaryLou, Mullen, Brian
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.06.1994
• Subjects: Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones - administration & dosage; Adrenal Cortex Hormones - adverse effects; Age Factors; Asthma; Asthma - drug therapy; Beclomethasone - adverse effects; Child; growth; Growth - drug effects; Humans; inhaled corticosteroids; steroid-dependent asthma; ICs; steroid-dependent asthma; growth; k; Asthma; inhaled corticosteroids; BDP
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/S0091-6749(94)70043-5

This analysis summarizes studies comparing attained heights with expected heights of children with asthma treated with inhaled or oral corticosteroids. The possible moderating effects of treatment duration, and dosage and asthma severity are also examined. A preliminary database of 95 articles rendered 21 includable studies representing 810 patients with asthma, which yielded 29 tests of the corticosteroid-growth effect. Statistical integration of the results of these studies revealed a significant but small tendency for corticosteroid therapy in general to be associated with diminished final height (Z = 2.328, p = 0.01, mean r = –0.023). However, this effect varied for the specific drugs under consideration. As expected, significant weak growth impairment was observed for prednisone (Z = 2.137, p = 0.0164, mean r = –0.295) and “other oral corticosteroids” (Z = 9.107, p = 2.44E-18, mean r = –0.260). On the other hand, a significant moderate tendency was observed for inhaled beclomethansone dipropionate therapy to be associated with attaining normal stature (Z = 7.395, p = 2.17E-13, mean r = +0.432). There was no statistical evidence for beclomethasone dipropionate therapy to be associated with growth impairment at higher doses, for longer therapy durations, or among patients with more severe asthma. This meta-analytic integration indicates that available studies of inhaled beclomethasone dipropionate therapy do not show an association between its use and the adverse effect of diminished stature. (J A LLERGY C LIN I MMUNOL 1994;93:967-76.)