Intake of 25 g of soybean protein with or without soybean fiber alters plasma lipids in men with elevated cholesterol concentrations

• Published in: The Journal of nutrition Vol. 124; no. 2; pp. 213 - 222
• Main Authors: Bakhit, R.M, Klein, B.P, Essex-Sorlie, D, Ham, J.O, Erdman, J.W. Jr, Potter, S.M
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Nutritional Sciences 01.02.1994
• Subjects: Adult; Aged; Apolipoproteins - analysis; Biological and medical sciences; Caseins - administration & dosage; CHOLESTEROL; Cholesterol - blood; Cholesterol, Dietary - administration & dosage; COLESTEROL; Dietary Fats - administration & dosage; Dietary Fiber; Disorders of blood lipids. Hyperlipoproteinemia; FIBRA DE LA DIETA; FIBRE ALIMENTAIRE; Glycine max; HOMBRES; HOMME; Humans; Hypercholesterolemia - diet therapy; LIPEMIA; LIPEMIE; Lipids - blood; LIPOPROTEINAS; LIPOPROTEINE; Male; Medical sciences; Metabolic diseases; Middle Aged; Plant Proteins, Dietary - administration & dosage; PLASMA SANGUIN; PLASMA SANGUINEO; PROTEINAS VEGETALES; PROTEINE VEGETALE; SOJA; Soybean Proteins; TRASTORNOS METABOLICOS; TRIGLICERIDOS; TRIGLYCERIDE; Triglycerides - blood; TROUBLE DU METABOLISME; Human; Nutrition; Cholesterolemia; Soy product; Metabolic diseases; Lipids; Hyperlipoproteinemia; Supplemented diet; Soybean; Cholesterol; Feeding; Soy protein; Hypercholesterolemia; Lipemia; Dietary fiber; Restricted diet
• ISSN: 0022-3166; 1541-6100
• DOI: 10.1093/jn/124.2.213

Twenty-one mildly hypercholesterolemic men consumed a diet that was low in fat 30% Of energy) and cholesterol (300 mg/d) and were given muffins containing 25 g protein + 20 g dietary fiber daily from either isolated soybean protein + soybean cotyledon fiber, isolated soybean protein + cellulose, casein + soybean cotyledon fiber or casein + cellulose. All subjects progressed through the low fat, low cholesterol baseline period, lasting 2 wk, and then through all four dietary treatments, lasting 4 wk each, according to a Latin square design. Plasma concentrations of total, LDL, HDL and VLDL cholesterol, total and VLDL triacylglycerols, and apolipoprotein A-I and B were measured at the end of each period. When data from all subjects were analyzed, dietary treatments did not influence lipemia; however, in subjects with initial total cholesterol concentrations 5.7 mmol/L, both isolated soybean protein treatments resulted in significantly lower total cholesterol compared with the two casein treatments p 0.05). In addition, a negative linear relationship was observed when a subject's total or LDL cholesterol change after each of the soybean treatments was regressed against the subject's baseline cholesterol concentration (P 0.05). Apolipoprotein A-1 varied dependent on baseline cholesterol with no apparent pattern, whereas apolipoprotein B levels were not affected. Results indicate that consumption of 25 g soybean protein/d is associated with lower total cholesterol concentrations in individuals with initial cholesterol concentrations 5.7 mmol/L