Effect of increasing the plasma oxygen diffusivity on experimental cryogenic edema

Mongrel cats with experimental cryogenic brain lesions were treated with the carotenoid compound crocetin. It has been shown that crocetin increases the diffusion speed of oxygen through plasma, and should provide a net increase in available oxygen to the capillary endothelial cell. The treated grou...

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Bibliographic Details
Published inJournal of neurosurgery Vol. 45; no. 5; p. 535
Main Authors Gainer, Jr, J V, Nugent, R
Format Journal Article
LanguageEnglish
Published United States 01.11.1976
Subjects
Animals
Brain Edema - drug therapy
Brain Edema - metabolism
Carotenoids - therapeutic use
Cats
Dexamethasone - therapeutic use
Female
Male
Oxygen - blood
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Summary:Mongrel cats with experimental cryogenic brain lesions were treated with the carotenoid compound crocetin. It has been shown that crocetin increases the diffusion speed of oxygen through plasma, and should provide a net increase in available oxygen to the capillary endothelial cell. The treated group of animals showed a significant reduction in edema as compared to a comparable control group. It is suggested that oxygen availability is an important factor in vasogenic edema.
ISSN:0022-3085
DOI:10.3171/jns.1976.45.5.0535