Evaluation of oxygenation in the surface layers of biological tissues based on diffuse optical spectroscopy with automated calibration of measurements

To assess the oxygen saturation (oxygenation) in the surface layers of biological tissues (at a depth of 4 mm), a compact system based on diffuse optical spectroscopy (DOS) with reflective measurement geometry in the wavelength range of 520 - 590 nm is proposed. The experimental DOS device is based...

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Bibliographic Details
Published inQuantum electronics (Woodbury, N.Y.) Vol. 49; no. 7; pp. 628 - 632
Main Authors Kleshnin, M.S., Turchin, I.V.
Format Journal Article
LanguageEnglish
Published Bristol Kvantovaya Elektronika, Turpion Ltd and IOP Publishing 01.07.2019
IOP Publishing
Subjects
60 APPLIED LIFE SCIENCES
ANIMAL TISSUES
automation of measurements
BLOOD VESSELS
Broadband
CALIBRATION
CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS
diffuse optical spectroscopy
Fiber optics
GEOMETRY
LAYERS
Luminous intensity
MONITORING
Occlusion
Optical fibers
OPTICS
optics of biological tissues
OXYGEN
Oxygen content
oxygen saturation
Oxygenation
SPECTROMETERS
Spectroscopic analysis
SPECTROSCOPY
Spectrum analysis
Surface layers
TESTING
Tissues
TRANSIENTS
VISIBLE RADIATION
WAVELENGTHS
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Summary:To assess the oxygen saturation (oxygenation) in the surface layers of biological tissues (at a depth of 4 mm), a compact system based on diffuse optical spectroscopy (DOS) with reflective measurement geometry in the wavelength range of 520 - 590 nm is proposed. The experimental DOS device is based on a broadband LED source of probe radiation and a spectrometer using a fibre-optic radiation delivery system. To calculate the oxygenation, an original method is proposed based on measuring the intensity of scattered light at four different locations of the source and receiver on the surface of the object under study (four-measurement method). The developed method allows for the device hardware parameters (optical contact with the tissue, transient characteristics of the radiation delivery system) and does not require any additional calibration measurements. The results of testing the DOS system using the four-measurement method for monitoring the oxygen saturation of tissues during the artificial occlusion of the blood vessels agree with the published data of other research teams.
ISSN:1063-7818
1468-4799
DOI:10.1070/QEL16940