Concordant rhabdoid tumor of the kidney in a set of identical twins with discordant outcomes
We report identical twin boys who each had stage IV rhabdoid tumor of the left kidney at the age of 5 months and 2 years, respectively. The 5-month-old boy, despite receiving chemotherapy, died of progressive disease at the age of 12 months. Following resection of the tumor, his twin brother was tre...
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Published in | Journal of pediatric hematology/oncology Vol. 25; no. 6; p. 491 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.06.2003
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Subjects | |
Online Access | Get more information |
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Summary: | We report identical twin boys who each had stage IV rhabdoid tumor of the left kidney at the age of 5 months and 2 years, respectively. The 5-month-old boy, despite receiving chemotherapy, died of progressive disease at the age of 12 months. Following resection of the tumor, his twin brother was treated with 6 cycles of combination chemotherapy consisting of cisplatinum, doxorubicin, vincristine, cyclophosphamide, and actinomycin-D alternating with ifosfamide and etoposide. After complete regression of lung and brain metastases, he received high-dose thiotepa, etoposide, and cyclophosphamide, followed by autologous peripheral stem cell rescue. The patient is presently alive and free of disease 6 years posttransplant. High-dose chemotherapy followed by autologous stem cell transplant may be an effective front-line therapeutic approach for patients with metastatic rhabdoid tumor of the kidney. |
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ISSN: | 1077-4114 |
DOI: | 10.1097/00043426-200306000-00013 |