Concordant rhabdoid tumor of the kidney in a set of identical twins with discordant outcomes

We report identical twin boys who each had stage IV rhabdoid tumor of the left kidney at the age of 5 months and 2 years, respectively. The 5-month-old boy, despite receiving chemotherapy, died of progressive disease at the age of 12 months. Following resection of the tumor, his twin brother was tre...

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Bibliographic Details
Published inJournal of pediatric hematology/oncology Vol. 25; no. 6; p. 491
Main Authors Sahdev, Indira, James-Herry, Angelica, Scimeca, Philip, Parker, Robert
Format Journal Article
LanguageEnglish
Published United States 01.06.2003
Subjects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Child, Preschool
Combined Modality Therapy
Diseases in Twins
Fatal Outcome
Humans
Infant
Kidney Neoplasms - pathology
Kidney Neoplasms - therapy
Male
Peripheral Blood Stem Cell Transplantation
Rhabdoid Tumor - pathology
Rhabdoid Tumor - therapy
Transplantation, Autologous
Treatment Outcome
Twins, Monozygotic
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Summary:We report identical twin boys who each had stage IV rhabdoid tumor of the left kidney at the age of 5 months and 2 years, respectively. The 5-month-old boy, despite receiving chemotherapy, died of progressive disease at the age of 12 months. Following resection of the tumor, his twin brother was treated with 6 cycles of combination chemotherapy consisting of cisplatinum, doxorubicin, vincristine, cyclophosphamide, and actinomycin-D alternating with ifosfamide and etoposide. After complete regression of lung and brain metastases, he received high-dose thiotepa, etoposide, and cyclophosphamide, followed by autologous peripheral stem cell rescue. The patient is presently alive and free of disease 6 years posttransplant. High-dose chemotherapy followed by autologous stem cell transplant may be an effective front-line therapeutic approach for patients with metastatic rhabdoid tumor of the kidney.
ISSN:1077-4114
DOI:10.1097/00043426-200306000-00013