Extensive nucleotide changes and deletions within the envelope glycoprotein gene of Euro-African West Nile viruses
FX Berthet, HG Zeller, MT Drouet, J Rauzier, JP Digoutte and V Deubel Institut Pasteur, Dakar, Senegal. We compared the sequence of an envelope protein gene fragment from 21 temporally distinct West Nile (WN) virus strains, isolated in nine African countries and in France. Alignment of nucleotide se...
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Published in | Journal of general virology Vol. 78; no. 9; pp. 2293 - 2297 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Soc General Microbiol
01.09.1997
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Subjects | |
Online Access | Get full text |
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Summary: | FX Berthet, HG Zeller, MT Drouet, J Rauzier, JP Digoutte and V Deubel
Institut Pasteur, Dakar, Senegal.
We compared the sequence of an envelope protein gene fragment from 21
temporally distinct West Nile (WN) virus strains, isolated in nine African
countries and in France. Alignment of nucleotide sequences defined two
groups of viruses which diverged by up to 29%. The first group of subtypes
is composed of nine WN strains from France and Africa. The Austral-Asian
Kunjin virus was classified as a WN subtype in this first group. The second
group includes 12 WN strains from Africa and Madagascar. Four strains
harboured a 12 nucleotide in-frame deletion. The loss of the corresponding
four amino acids resulted in the loss of the potential glycosylation site
present in several WN strains. The distribution of virus subtypes into two
lineages did not correlate with host preference or geographical origin. The
isolation of closely related subtypes in distant countries is consistent
with WN viruses being disseminated by migrating birds. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0022-1317 1465-2099 |
DOI: | 10.1099/0022-1317-78-9-2293 |