Oscillations in probability distributions for stochastic gene expression

The phenomenon of oscillations in probability distribution functions of number of components is found for a model of stochastic gene expression. It takes place in cases of low levels of molecules or strong intracellular noise. The oscillations distinguish between more probable even and less probable...

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Bibliographic Details
Published inThe Journal of chemical physics Vol. 140; no. 20; p. 205104
Main Authors Petrosyan, K G, Hu, Chin-Kun
Format Journal Article
LanguageEnglish
Published United States 28.05.2014
Subjects
Computer Simulation
Gene Expression Regulation
Genes
Probability
Proteins - chemistry
RNA, Messenger - chemistry
Stochastic Processes
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Summary:The phenomenon of oscillations in probability distribution functions of number of components is found for a model of stochastic gene expression. It takes place in cases of low levels of molecules or strong intracellular noise. The oscillations distinguish between more probable even and less probable odd number of particles. The even-odd symmetry restores as the number of molecules increases with the probability distribution function tending to Poisson distribution. We discuss the possibility of observation of the phenomenon in gene, protein, and mRNA expression experiments.
ISSN:1089-7690
DOI:10.1063/1.4875800