Lack of effect of riboflavin deficiency on vitamin B12-related metabolic pathways and fatty acid synthesis

• Published in: The American journal of clinical nutrition Vol. 32; no. 1; pp. 10 - 15
• Main Authors: Frenkel, Eugene P, Kitchens, Richard L, Savage, Howard E, Seibert, Richard A, Lane, Montague
• Format: Journal Article
• Language: English
• Published: United States 01.01.1979
• Subjects: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - metabolism; Animals; Brain - metabolism; Cobamides - biosynthesis; Cobamides - metabolism; Fatty Acids - biosynthesis; Flavins - pharmacology; Lipid Metabolism; Liver - enzymology; Male; Methylmalonyl-CoA Mutase - metabolism; Rats; Riboflavin - antagonists & inhibitors; Riboflavin Deficiency - metabolism; Vitamin B 12 - metabolism
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/32.1.10

Extract: The neurological sequelae of riboflavin deficiency posed the possibility that this tissue injury was mediated by defective vitamin B12 function. Studies of the B12 dependent enzymatic reactions in a riboflavin-deficient rat model documented normal B12 activity in liver and neural tissue. In addition, examination of neural lipids and separation and analysis of neural fatty acids failed to reveal the increased odd chain fatty acids characteristically seen in the B12-deficient state. Thus, the neural tissue sequelae of riboflavin deficiency do not appear to relate to B12 coenzyme functions