Clinical laboratory studies on a new topical corticosteroid—Triamcinolone acetonide

Triamcinolone acetonide, a new corticosteroid which has been suggested as a highly active topical agent in the treatment of certain acute and chronic lesions of the oral mucous membranes, was studied with respect to its possible systemic actions. In order to determine any undesirable effects inciden...

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Published inOral surgery, oral medicine, oral pathology Vol. 14; no. 8; pp. 938 - 941
Main Authors Kutscher, Austin H., Zegarelli, Edward V., Silvers, Herbert F., Piro, John D.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.1961
Subjects
Dermatologic Agents
Glucocorticoids
Humans
Lichen Planus - therapy
Old Medline
Stomatitis - therapy
Triamcinolone - therapy
Triamcinolone Acetonide
STOMATITIS/therapy
LICHEN PLANUS/therapy
TRIAMCINOLONE/therapy
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Summary:Triamcinolone acetonide, a new corticosteroid which has been suggested as a highly active topical agent in the treatment of certain acute and chronic lesions of the oral mucous membranes, was studied with respect to its possible systemic actions. In order to determine any undesirable effects incident to topical therapy, we undertook detailed blood chemistry, hematologic, and urine studies in eleven patients treated with this corticosteroid. A comparative study of the before- and after-treatment blood and urine test values following the five-day period of drug therapy (including 1 mg. per day of the active agent, triamcinolone acetonide) did not reveal any discernible or noteworthy deviations. All test findings remained within the accepted normal range. Where posttherapy deviations within the normal range were found, no consistent pattern was evident.
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ISSN:0030-4220
1878-2175
DOI:10.1016/0030-4220(61)90007-X