Malassezia virulence factors and their role in dermatological disorders

Malassezia is a commensal fungus that constitutes normal skin microbiota. However, in certain conditions and individuals, it may transform into a pathogenic yeast with multiple associated dermatological disorders and various clinical manifestations. This phenomenon is influenced by a unique host-age...

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Published inActa dermatovenerologica Alpina, Panonica, et Adriatica Vol. 31; no. 2; pp. 65 - 70
Main Authors Kurniadi, Ivan, Hendra Wijaya, Wong, Timotius, Kris Herawan
Format Journal Article
LanguageEnglish
Published Association of Slovenian Dermatovenerologists 01.01.2022
Subjects
Amino acids
Atopic dermatitis
Microbiota (Symbiotic organisms)
Psoriasis
Skin
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Summary:Malassezia is a commensal fungus that constitutes normal skin microbiota. However, in certain conditions and individuals, it may transform into a pathogenic yeast with multiple associated dermatological disorders and various clinical manifestations. This phenomenon is influenced by a unique host-agent interaction that triggers the production of several virulence factors, such as indoles, reactive oxygen species, azelaic acid, hyphae formation, and biofilm formation. This review article discusses Malassezia virulence factors that contribute to the transformation of Malassezia from commensal to pathogenic as well as their role in dermatological disorders, including pityriasis versicolor, seborrheic dermatitis, Malassezia folliculitis, atopic dermatitis, and psoriasis. Keywords: atopic dermatitis, Malassezia, pityriasis versicolor, psoriasis, seborrheic dermatitis, virulence factors
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1318-4458
1318-4458
1581-2979
DOI:10.15570/actaapa.2022.8