Hyposplenism and Gastrointestinal Diseases: Significance and Mechanisms

Background: Functional hyposplenism is a recognized complication of several gastroenterological disorders, including coeliac and inflammatory bowel diseases, and is believed to contribute to the increased infection risk seen in these disorders. Summary: The mechanisms of hyposplenism are poorly unde...

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Published inDigestive diseases (Basel) Vol. 40; no. 3; pp. 290 - 298
Main Authors Mathur, Abhinav, McLean, Mairi H., Cao, Huan, Vickers, Mark A.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland 01.01.2022
Subjects
Small and Large Bowel: Review Article
Hyposplenism
Spleen
Inflammatory bowel disease
Coeliac disease
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Summary:Background: Functional hyposplenism is a recognized complication of several gastroenterological disorders, including coeliac and inflammatory bowel diseases, and is believed to contribute to the increased infection risk seen in these disorders. Summary: The mechanisms of hyposplenism are poorly understood. In this article, we review possible mechanisms underlying development of functional hyposplenism and discuss implications for its management. Key Messages: Identifying functional hyposplenism is important, as it may permit earlier recognition and treatment of serious infections through patient education and vaccination.
ISSN:0257-2753
1421-9875
DOI:10.1159/000517338