Tumors face NO problems?

The effect of nitric oxide (NO) synthase (NOS) II expression on cancer biology is unclear and difficult to define, with multiple reports of pro- and anti-cancer actions. Here we address the major factors that seem likely to account for these paradoxical behaviors, which include variability in NO pro...

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Bibliographic Details
Published inCancer research (Chicago, Ill.) Vol. 66; no. 13; pp. 6459 - 6462
Main Authors Lancaster, Jr, Jack R, Xie, Keping
Format Journal Article
LanguageEnglish
Published United States 01.07.2006
Subjects
Animals
Cell Death - physiology
Humans
Neoplasms - enzymology
Neoplasms - metabolism
Neoplasms - pathology
Nitric Oxide - metabolism
Nitric Oxide - physiology
Nitric Oxide Synthase Type II - biosynthesis
Nitric Oxide Synthase Type II - metabolism
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Summary:The effect of nitric oxide (NO) synthase (NOS) II expression on cancer biology is unclear and difficult to define, with multiple reports of pro- and anti-cancer actions. Here we address the major factors that seem likely to account for these paradoxical behaviors, which include variability in NO production, heterogeneity in NO chemistry (and thus its cellular actions), and differential cellular responses. In addition, we suggest that a major determinant of the outcome of NO actions in the tumor environment is cellular adaptation/selection to the cytotoxic actions of NO.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.CAN-05-2900